Hotel Destination 21 is located in Stadtbezirk 5, a neighborhood in Düsseldorf, and is near a metro station. Tonhalle Duesseldorf and Tonhalle Concert Hall are cultural highlights, and travelers looking to shop may want to visit Kö-Bogen and Konigsallee. Theatermuseum Dusseldorf and Rheinufer are also worth visiting.