OYO 2S Hotel is located in Florianópolis Centro, a neighborhood in Florianópolis. The area's natural beauty can be seen at Praia do Campeche and Serra do Tabuleiro state park, while Alvaro Carvalho Theater and Historical Museum of Santa Catarina are cultural highlights. Museu do Homem do Sambaqui and UFSC Planetarium are also worth visiting.